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The Biology of the Sodium Iodide Symporter and its Potential for Targeted Gene Delivery

1 Mar 2010

Abstract excerpt

The sodium iodide symporter (NIS) is responsible for thyroidal, salivary, gastric, intestinal and mammary iodide uptake. It was first cloned from the rat in 1996 and shortly thereafter from human and mouse tissue. In the intervening years, we have learned a great deal about the biology of NIS. Detailed knowledge of its genomic structure, transcriptional and post-transcriptional regulation and pharmacological...

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PMID: 20201784
DOI: 10.2174/156800910791054194

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