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Article

Radioiodine Therapy in Differentiated Thyroid Cancer: The First Targeted Therapy in Oncology

1 Jan 2014

Abstract excerpt

Iodide uptake across the membranes of thyroid follicular cells and cancer cells occurs through an active transport process mediated by the sodium-iodide symporter (NIS). The rat and human NIS-coding genes were cloned and identified in 1996. Evaluation of NIS gene and protein expression is critical for the management of thyroid cancer, and several approaches to increase NIS levels have been tried. Identification...

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Identifiers

PMID: 25309780
DOI: 10.3803/enm.2014.29.3.233

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