Article
CCK2 receptor expression transforms non-tumorigenic human NCM356 colonic epithelial cells into tumor forming cells.
International journal of cancer - 15 Feb 2010
Chao Celia, Han Xueliang, Ives Kirk, Park Jeseong, Kolokoltsov Andrey A, Davey Robert A, Moyer Mary P, Hellmich Mark R
Abstract excerpt
Expression of gastrin and cholecystokinin 2 (CCK(2)) receptor splice variants (CCK(2)R and CCK(2i4sv)R) are upregulated in human colonic adenomas where they are thought to contribute to tumor growth and progression. To determine the effects of ectopic CCK(2) receptor variant expression on colonic epithelial cell growth in vitro and in vivo, we employed the non-tumorigenic colonic epithelial cell line, NCM356....
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