Article

Expression, Exon-Intron Organization, and Chromosome Mapping of the Human Sodium Iodide Symporter

1997-08-01

Abstract excerpt

The active iodide uptake of the thyroid gland in humans is mediated by the human sodium iodide symporter (hNIS). In this report, we show that hNIS expression was detected primarily in thyroid tissue, but also in breast, colon, and ovary tissues. Expression of hNIS is greatly reduced in thyroid tumors compared to normal thyroid tissue. Among tumor tissues, hNIS expression appears to be variable, consistent with the...

Topics

Open a Topic to create a Post that cites this publication.

Thyroid Cancer Diagnosis and Treatment

Identifiers and source

Literature Corpus work: f74929f4-acdc-5e02-a82a-75c9dbf0d4b2
DOI: 10.1210/en.138.8.3555

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Expression, Exon-Intron Organization, and Chromosome Mapping of the Human Sodium Iodide SymporterDOI 10.1210/en.138.8.3555Read

Expression, Exon-Intron Organization, and Chromosome Mapping of the Human Sodium Iodide SymporterSemantic proximity Read

Iodide Symporter Gene Expression in Human Thyroid TumorsSemantic proximity Read

The sodium/iodide Symporter (NIS): characterization, regulation, and medical significance.Semantic proximity Read

The sodium iodide symporter: its pathophysiological and therapeutic implications.Semantic proximity Read

Differential regulation of the human sodium/iodide symporter gene promoter in papillary thyroid carcinoma cell lines and normal thyroid cells.Semantic proximity Read

The Biology of the Sodium Iodide Symporter and its Potential for Targeted Gene DeliverySemantic proximity Read

Expression of the Na+/I- Symporter Gene in Human Thyroid Tumors: A Comparison Study with Other Thyroid-Specific GenesSemantic proximity Read

Endogenous expression of the sodium iodide symporter mediates uptake of iodide in murine models of colorectal carcinoma.Semantic proximity Read

Novel, missense and loss-of-function mutations in the sodium/iodide symporter gene causing iodide transport defect in three Japanese patients.Semantic proximity Read

Radioiodine Therapy in Differentiated Thyroid Cancer: The First Targeted Therapy in OncologySemantic proximity Read

A homozygous missense mutation of the sodium/iodide symporter gene causing iodide transport defect.Semantic proximity Read

A thyroid-specific far-upstream enhancer in the human sodium/iodide symporter gene requires Pax-8 binding and cyclic adenosine 3',5'-monophosphate response element-like sequence binding proteins for full activity and is differentially regulated in normal and thyroid cancer cells.Semantic proximity Read