Article

New mechanisms of radioiodide uptake revealed via a novel high throughput drug screening approach in thyroid cancer

2020-07-22

Abstract excerpt

<h4>ABSTRACT</h4> New combinatorial drug strategies are urgently needed to improve radioiodide (RAI) uptake and efficiently ablate thyroid cancer cells, thereby addressing recurrent and metastatic disease. Cellular iodide uptake is accomplished solely by the sodium iodide symporter (NIS), but the complexity of NIS functional regulation and a lack of amenable high-throughput screening assays has impeded progress....

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Literature Corpus work: 6473fca3-9efa-582e-b44c-ca010112a950
DOI: 10.1101/2020.07.21.213967

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