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Article

The sodium/iodide Symporter (NIS): characterization, regulation, and medical significance.

Endocrine reviews - 1 Feb 2003

Dohán Orsolya, De la Vieja Antonio, Paroder Viktoriya, Riedel Claudia, Artani Mona, Reed Mia, Ginter Christopher S, Carrasco Nancy

Abstract excerpt

The Na(+)/I(-) symporter (NIS) is an integral plasma membrane glycoprotein that mediates active I(-) transport into the thyroid follicular cells, the first step in thyroid hormone biosynthesis. NIS-mediated thyroidal I(-) transport from the bloodstream to the colloid is a vectorial process made possible by the selective targeting of NIS to the basolateral membrane. NIS also mediates active I(-) transport in other...

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Identifiers

PMID: 12588808
DOI: 10.1210/er.2001-0029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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