Article
Chromosomal instability predicts metastatic disease in patients with insulinomas.
Endocrine-related cancer - 1 Jun 2005
Jonkers Y M H, Claessen S M H, Perren A, Schmid S, Komminoth P, Verhofstad A A, Hofland L J, de Krijger R R, Slootweg P J, Ramaekers F C S, Speel E-J M
Abstract excerpt
Endocrine pancreatic tumors (EPTs) comprise a highly heterogeneous group of tumors with different clinical behavior and genetic makeup. Insulinomas represent the predominant syndromic subtype of EPTs. The metastatic potential of insulinomas can frequently not be predicted using histopathological criteria, and also molecular markers indicating malignant progression are unreliable because of the small number of...
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