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Article

Influence of multidrug resistance and drug transport proteins on chemotherapy drug metabolism

2 Apr 2015

Abstract excerpt

INTRODUCTION: Chemotherapy involving the use of anticancer drugs remains an important strategy in the overall management of patients with metastatic cancer. Acquisition of multidrug resistance remains a major impediment to successful chemotherapy. Drug transporters in cell membranes and intracellular drug metabolizing enzymes contribute to the resistance phenotype and determine the pharmacokinetics of anticancer...

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PMID: 25836015
DOI: 10.1517/17425255.2015.1028356

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