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Article

Efflux Transporters and their Clinical Relevance

1 Feb 2005

Abstract excerpt

It is increasingly recognized that efflux transporters play an important role, not only in chemo protection e.g. multi-drug resistance, but also in the absorption, distribution, and elimination of drugs. The modulation of drug transporters through inhibition or induction can lead to significant drug-drug interactions by affecting intestinal absorption, renal secretion, and biliary excretion, thereby changing the...

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PMID: 15720288
DOI: 10.2174/1389557053402756

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