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Article

The MRP Family and Anticancer Drug Metabolism

1 Dec 2001

Abstract excerpt

Acquirement of drug resistance by tumor cells is a major chemotherapeutic problem. It is well known that typical multidrug resistance is caused by P-glycoprotein and multidrug resistance related protein (MRP1) which belong to the ATP binding cassette (ABC) transporter family. Ishikawa proposed that the ATP-dependent glutathione-S-conjugate export pump (GS-X pump) and phase III detoxification system are essential...

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PMID: 11766988
DOI: 10.2174/1389200013338289

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