Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phosphorylation of AKT/PKB by CK2 is necessary for the AKT-dependent up-regulation of β-catenin transcriptional activity.

Journal of cellular physiology - 1 Jul 2011

Ponce Daniela P, Maturana Jose L, Cabello Pablo, Yefi Roger, Niechi Ignacio, Silva Eduardo, Armisen Ricardo, Galindo Mario, Antonelli Marcelo, Tapia Julio C

Abstract excerpt

β-Catenin is a key protein in the canonical Wnt signaling pathway and in many cancers alterations in transcriptional activity of its components are observed. This pathway is up-regulated by the protein kinase CK2, but the underlying mechanism of this change is unknown. It has been demonstrated that CK2 hyperactivates AKT/PKB by phosphorylation at Ser129, and AKT phosphorylates β-catenin at Ser552, which in turn,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta Catenin
Share to Casein Kinase II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Survival

Share to Inhibitor of Apoptosis Proteins

Share to Proto-Oncogene Proteins c-akt

Share to Serine

Share to Survivin

Share to Up-Regulation

Source

Identifiers

PMID: 21506126
DOI: 10.1002/jcp.22527

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphorylation of AKT/PKB by CK2 is necessary for the AKT-dependent up-regulation of β-catenin transcriptional activity.PMID 21506126Read ↗

CK2 as a positive regulator of Wnt signalling and tumourigenesis.Semantic proximity Read ↗

Therapeutic CK2 inhibition attenuates diverse prosurvival signaling cascades and decreases cell viability in human breast cancer cellsSemantic proximity Read ↗

Protein kinase CK2 phosphorylates and upregulates Akt/PKB.Semantic proximity Read ↗

BMI1, a new target of CK2α.Semantic proximity Read ↗

Regulation of PTEN by CK2 and Notch1 in primary T-cell acute lymphoblastic leukemia: rationale for combined use of CK2- and gamma-secretase inhibitors.Semantic proximity Read ↗

Effect of casein kinase 1α inhibition on autophagy flux and the AKT/phospho-β-catenin (S552) axis in HCT116, a RAS-mutated colorectal cancer cell line.Semantic proximity Read ↗

AKT1 E17K Inhibits Cancer Cell Migration by Abrogating β-Catenin Signaling.Semantic proximity Read ↗

AKT1/PKBα Kinase Is Frequently Elevated in Human Cancers and Its Constitutive Activation Is Required for Oncogenic Transformation in NIH3T3 CellsSemantic proximity Read ↗

Protein kinase CK2 catalyzes tyrosine phosphorylation in mammalian cells.Semantic proximity Read ↗

Threonine 393 of beta-catenin regulates interaction with Axin.Semantic proximity Read ↗

CK1ε Is Required for Breast Cancers Dependent on β-Catenin ActivitySemantic proximity Read ↗

Protein kinase C ϵ stabilizes β-catenin and regulates its subcellular localization in podocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.