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Article

Discovery of Small-Molecule Inhibitors of the PTK7/β-Catenin Interaction Targeting the Wnt Signaling Pathway in Colorectal Cancer.

ACS chemical biology - 20 May 2022

Ganier Laetitia, Betzi Stephane, Derviaux Carine, Roche Philippe, Dessaux Charlotte, Muller Christophe, Hoffer Laurent, Morelli Xavier, Borg Jean-Paul

Abstract excerpt

Colorectal cancer (CRC), the second cause of death due to cancer worldwide, is a major public health issue. The discovery of new therapeutic targets is thus essential. Pseudokinase PTK7 intervenes in the regulation of the Wnt/β-catenin pathway signaling, in part, through a kinase domain-dependent interaction with the β-catenin protein. PTK7 is overexpressed in CRC, an event associated with metastatic development...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35483008
DOI: 10.1021/acschembio.1c00826

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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