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Article

A novel in vitro multiple-stress dormancy model for Mycobacterium tuberculosis generates a lipid-loaded, drug-tolerant, dormant pathogen.

PloS one - 29 Jun 2009

Deb Chirajyoti, Lee Chang-Muk, Dubey Vinod S, Daniel Jaiyanth, Abomoelak Bassam, Sirakova Tatiana D, Pawar Santosh, Rogers Linda, Kolattukudy Pappachan E

Abstract excerpt

BACKGROUND: Mycobacterium tuberculosis (Mtb) becomes dormant and phenotypically drug resistant when it encounters multiple stresses within the host. Inability of currently available drugs to kill latent Mtb is a major impediment to curing and possibly eradicating tuberculosis (TB). Most in vitro dormancy models, using single stress factors, fail to generate a truly dormant Mtb population. An in vitro model that...

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Identifiers

PMID: 19562030
DOI: 10.1371/journal.pone.0006077
PMCID: PMC2698117

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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