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Article

Wax ester synthesis is required for Mycobacterium tuberculosis to enter in vitro dormancy.

PloS one - 1 Jan 2012

Sirakova Tatiana D, Deb Chirajyoti, Daniel Jaiyanth, Singh Harminder D, Maamar Hedia, Dubey Vinod S, Kolattukudy Pappachan E

Abstract excerpt

Mycobacterium tuberculosis (Mtb) is known to produce wax esters (WE) when subjected to stress. However, nothing is known about the enzymes involved in biosynthesis of WE and their role in mycobacterial dormancy. We report that two putative Mtb fatty acyl-CoA reductase genes (fcr) expressed in E. coli display catalytic reduction of fatty acyl-CoA to fatty aldehyde and fatty alcohol. Both enzymes (FCR1/Rv3391) and...

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Identifiers

PMID: 23272127
DOI: 10.1371/journal.pone.0051641
PMCID: PMC3522743

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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