Article
Mycobacterium tuberculosis transcriptional adaptation, growth arrest and dormancy phenotype development is triggered by vitamin C.
PloS one - 27 May 2010
Taneja Neetu Kumra, Dhingra Sakshi, Mittal Aditya, Naresh Mohit, Tyagi Jaya Sivaswami
Abstract excerpt
BACKGROUND: Tubercle bacilli are thought to persist in a dormant state during latent tuberculosis (TB) infection. Although little is known about the host factors that induce and maintain Mycobacterium tuberculosis (M. tb) within latent lesions, O(2) depletion, nutrient limitation and acidification are some of the stresses implicated in bacterial dormancy development/growth arrest. Adaptation to hypoxia and...
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