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Article

A conserved hydrophobic surface of the LARG pleckstrin homology domain is critical for RhoA activation in cells.

Cellular signalling - 1 Nov 2009

Aittaleb Mohamed, Gao Guang, Evelyn Chris R, Neubig Richard R, Tesmer John J G

Abstract excerpt

Leukemia associated Rho guanine nucleotide exchange factor (LARG) activates RhoA in response to signals received by specific classes of cell surface receptors. The catalytic core of LARG is a Dbl homology (DH) domain whose activity is modulated by an adjacent pleckstrin homology (PH) domain. In this study, we used a transcriptional assay and confocal microscopy to examine the roles of several novel structural...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP-Binding Protein alpha Subunits, G12-G13

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Identifiers

PMID: 19560536
DOI: 10.1016/j.cellsig.2009.06.003
PMCID: PMC2735620

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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