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Article

Activated RhoA is a positive feedback regulator of the Lbc family of Rho guanine nucleotide exchange factor proteins.

The Journal of biological chemistry - 19 Apr 2013

Medina Frank, Carter Angela M, Dada Olugbenga, Gutowski Stephen, Hadas Jana, Chen Zhe, Sternweis Paul C

Abstract excerpt

The monomeric Rho GTPases are essential for cellular regulation including cell architecture and movement. A direct mechanism for hormonal regulation of the RhoA-type GTPases is their modulation by the G12 and G13 proteins via RH (RGS homology) containing RhoGEFs. In addition to the interaction of the G protein α subunits with the RH domain, activated RhoA also binds to the pleckstrin homology (PH) domain of...

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Identifiers

PMID: 23493395
DOI: 10.1074/jbc.M113.450056
PMCID: PMC3630898

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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