Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modulation of oncogenic DBL activity by phosphoinositol phosphate binding to pleckstrin homology domain.

The Journal of biological chemistry - 1 Jun 2001

Russo C, Gao Y, Mancini P, Vanni C, Porotto M, Falasca M, Torrisi M R, Zheng Y, Eva A

Abstract excerpt

The Dbl family guanine nucleotide exchange factors (GEFs) contain a region of sequence similarity consisting of a catalytic Dbl homology (DH) domain in tandem with a pleckstrin homology (PH) domain. PH domains are involved in the regulated targeting of signaling molecules to plasma membranes by p...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Proteins
Share to cdc42 GTP-Binding Protein
Share to Guanine Nucleotide Exchange Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Guanosine Diphosphate

Share to Guanosine Triphosphate

Share to Microscopy, Immunoelectron

Share to Phosphatidylinositol 4,5-Diphosphate

Share to Phosphatidylinositol Phosphates

Source

Identifiers

PMID: 11278560
DOI: 10.1074/jbc.M009742200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11278560-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modulation of oncogenic DBL activity by phosphoinositol phosphate binding to pleckstrin homology domain.PMID 11278560Read ↗

Regulation of proto-Dbl by intracellular membrane targeting and protein stability.Semantic proximity Read ↗

On the mechanism of autoinhibition of the RhoA-specific nucleotide exchange factor PDZRhoGEF.Semantic proximity Read ↗

Identification and characterization of hPEM-2, a guanine nucleotide exchange factor specific for Cdc42.Semantic proximity Read ↗

Role of the C-terminal SH3 domain and N-terminal tyrosine phosphorylation in regulation of Tim and related Dbl-family proteins.Semantic proximity Read ↗

Oligomerization of DH domain is essential for Dbl-induced transformation.Semantic proximity Read ↗

The pleckstrin homology domain of the Arf6-specific exchange factor EFA6 localizes to the plasma membrane by interacting with phosphatidylinositol 4,5-bisphosphate and F-actin.Semantic proximity Read ↗

Phosphatidylinositol (3,4,5)-trisphosphate specifically interacts with the phox homology domain of phospholipase D1 and stimulates its activity.Semantic proximity Read ↗

Critical role of the pleckstrin homology and cysteine-rich domains in Vav signaling and transforming activity.Semantic proximity Read ↗

Mechanistic insights into the phosphatidylinositol binding properties of the pleckstrin homology domain of lamellipodin.Semantic proximity Read ↗

Phosphatidylserine binding is essential for plasma membrane recruitment and signaling function of 3-phosphoinositide-dependent kinase-1.Semantic proximity Read ↗

Analysis of phosphoinositide binding by pleckstrin homology domain from dynamin.Semantic proximity Read ↗

Dual role for phosphoinositides in regulation of yeast and mammalian phospholipase D enzymes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.