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Article

Synapsis and DNA cleavage in phiC31 integrase-mediated site-specific recombination.

Nucleic acids research - 1 Jan 2004

Smith Matthew C A, Till Rob, Brady Kevin, Soultanas Panos, Thorpe Helena, Smith Margaret C M

Abstract excerpt

The Streptomyces phage phiC31 encodes an integrase belonging to the serine recombinase family of site-specific recombinases. The well studied serine recombinases, the resolvase/invertases, bring two recombination sites together in a synapse, and then catalyse a concerted four-strand staggered break in the DNA substrates whilst forming transient covalent attachments with the recessed 5' ends. Rotation of one pair...

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Source

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Identifiers

PMID: 15141031
DOI: 10.1093/nar/gkh538
PMCID: PMC419440

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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