Article
Architecture of a serine recombinase-DNA regulatory complex.
Molecular cell - 25 Apr 2008
Mouw Kent W, Rowland Sally-J, Gajjar Mark M, Boocock Martin R, Stark W Marshall, Rice Phoebe A
Abstract excerpt
An essential feature of many site-specific recombination systems is their ability to regulate the direction and topology of recombination. Resolvases from the serine recombinase family assemble an interwound synaptic complex that harnesses negative supercoiling to drive the forward reaction and promote recombination between properly oriented sites. To better understand the interplay of catalytic and regulatory...
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