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Article

The Hin recombinase assembles a tetrameric protein swivel that exchanges DNA strands.

Nucleic acids research - 1 Aug 2009

Dhar Gautam, McLean Meghan M, Heiss John K, Johnson Reid C

Abstract excerpt

Most site-specific recombinases can be grouped into two structurally and mechanistically different classes. Whereas recombination by tyrosine recombinases proceeds with little movements by the proteins, serine recombinases exchange DNA strands by a mechanism requiring large quaternary rearrangements. Here we use site-directed crosslinking to investigate the conformational changes that accompany the formation of...

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Identifiers

PMID: 19515933
DOI: 10.1093/nar/gkp466
PMCID: PMC2724282

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