Article
Regulatory mutations in Sin recombinase support a structure-based model of the synaptosome.
Molecular microbiology - 1 Oct 2009
Rowland Sally-J, Boocock Martin R, McPherson Arlene L, Mouw Kent W, Rice Phoebe A, Stark W Marshall
Abstract excerpt
The resolvase Sin regulates DNA strand exchange by assembling an elaborate interwound synaptosome containing catalytic and regulatory Sin tetramers, and an architectural DNA-bending protein. The crystal structure of the regulatory tetramer was recently solved, providing new insights into the structural basis for regulation. Here we describe the selection and characterization of two classes of Sin mutations that,...
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