Article
Structural and dynamic basis of a supercoiling-responsive DNA element.
Nucleic acids research - 1 Jan 2006
Bae Sung-Hun, Yun Sang Hoon, Sun Dawei, Lim Heon M, Choi Byong-Seok
Abstract excerpt
In both eukaryotes and prokaryotes, negative supercoiling of chromosomal DNA acts locally to regulate a variety of cellular processes, such as transcription, replication, recombination and response to environmental stresses. While studying the interaction between the Hin recombinase and mutated versions of its cognate DNA-binding site, we identified a mutated DNA site that binds Hin only when the DNA is...
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