Article
A pharmacogenetic study of polymorphisms in interferon pathway genes and response to interferon-alpha treatment in chronic hepatitis B patients.
Antiviral research - 1 Sept 2009
Wu Xiaopan, Zhu Xilin, Zhu Shuying, Li Jingyun, Ma Juan, Li Zhuo, Li Hui, Liu Ying
Abstract excerpt
Certain host genetic polymorphisms in interferon (IFN) signaling pathway genes are reported to be associated with response to IFNalpha therapy. We studied 10 single nucleotide polymorphisms (SNPs) in IFN signaling pathway genes to examine their associations with response to IFN treatment in chronic hepatitis B (CHB) patients. Two hundred and forty-six IFNalpha treatment-naïve CHB patients were enrolled for the...
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