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Article

An interferon response gene signature is associated with the therapeutic response of hepatitis C patients.

PloS one - 1 Jan 2014

Pfeffer Lawrence M, Li Kui, Fleckenstein Jaquelyn F, Marion Tony N, Diament Joel, Yang Chuan He, Pfeffer Susan R, Fan Meiyun, Handorf Elizabeth, Handorf Charles R

Abstract excerpt

Infection with the hepatitis C virus (HCV) is a major cause of chronic liver diseases and hepatocellular carcinoma worldwide, and thus represents a significant public health problem. The type I interferon (IFN), IFNα, has been successful in treating HCV-infected patients, but current IFN-based treatment regimens for HCV have suboptimal efficacy, and relatively little is known about why IFN therapy eliminates the...

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Source

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Identifiers

PMID: 25111807
DOI: 10.1371/journal.pone.0104202
PMCID: PMC4128657

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Source receipt: pubmed, retrieved 7 Sept 2026.

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