Article
JAK1 gene polymorphisms are associated with the outcomes of hepatitis B virus infection, but not with α interferon therapy response in a Han Chinese population.
Genetic testing and molecular biomarkers - 1 Oct 2012
Chen Kangmei, Min Hanyi, Wu Xiaopan, Zhu Xilin, Li Zhuo, Li Hui, Liu Ying
Abstract excerpt
AIMS: Janus kinase 1 (JAK1) is a key member in the interferon (IFN) signaling pathway. Recent studies suggested single-nucleotide polymorphisms (SNPs) in IFN pathway genes are associated with outcomes of hepatitis B virus (HBV) infection and response to IFNα therapy. The aim of the study is to investigate whether SNPs in JAK1 were associated with outcomes of HBV infection and response to IFNα therapy. METHODS: We...
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