Article
Association study in Romanians confirms IL23A gene haplotype block rs2066808/rs11171806 as conferring risk to psoriatic arthritis.
Cytokine - 1 Jul 2013
Popa Olivia Mihaela, Kriegova Eva, Popa Luis, Schneiderova Petra, Dutescu Monica Irina, Bojinca Mihai, Bara Constantin, Petrek Martin
Abstract excerpt
BACKGROUND: The cytokines IL12 and IL23 have been recently implicated in the pathogenesis of psoriatic arthritis (PsA). In this study we investigated the genetic variations in the genes coding for IL12, IL23 and IL23 receptor as a plausible source of susceptibility and modification of clinical symptoms of PsA in Romanian population. METHODS: Twenty five SNPs mapping to IL12A, IL12B, IL23A, IL23R and IL12RB1 genes...
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