Article
IL13 promoter polymorphism 1112C/T modulates the adverse effect of tobacco smoking on lung function.
American journal of respiratory and critical care medicine - 15 Oct 2007
Sadeghnejad Alireza, Meyers Deborah A, Bottai Matteo, Sterling David A, Bleecker Eugene R, Ohar Jill A
Abstract excerpt
RATIONALE: Although the duration and amount of cigarette smoking correlate with reduction in pulmonary function, there is still variation among individual responses. IL-13 is involved in pulmonary inflammation, remodeling, and susceptibility to chronic obstructive pulmonary disease (COPD). OBJECTIVES: We investigated whether the relationships between smoking and the lung function measures FEV(1) and FEV(1)/FVC...
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