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Mutational Analysis of Merkel Cell Carcinoma

17 Oct 2014

Abstract excerpt

Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine malignancy that is associated with a poor prognosis. The pathogenesis of MCC is not well understood, and despite a recent plethora of mutational analyses, we have yet to find a set of signature mutations implicated in the majority of cases. Mutations, including TP53, Retinoblastoma and PIK3CA, have been documented in subsets of patients. Other...

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PMID: 25329450
DOI: 10.3390/cancers6042116

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