Article
The Distinctive Mutational Spectra of Polyomavirus-Negative Merkel Cell Carcinoma.
Cancer research - 15 Sept 2015
Harms Paul William, Vats Pankaj, Verhaegen Monique Elise, Robinson Dan R, Wu Yi-Mi, Dhanasekaran Saravana Mohan, Palanisamy Nallasivam, Siddiqui Javed, Cao Xuhong, Su Fengyun, Wang Rui, Xiao Hong, Kunju Lakshmi P, Mehra Rohit, Tomlins Scott A, Fullen Douglas Randall, Bichakjian Christopher Keram, Johnson Timothy M, Dlugosz Andrzej Antoni, Chinnaiyan Arul M
Abstract excerpt
Merkel cell carcinoma (MCC) is a rare but highly aggressive cutaneous neuroendocrine tumor. Merkel cell polyomavirus (MCPyV) may contribute to tumorigenesis in a subset of tumors via inhibition of tumor suppressors such as retinoblastoma (RB1) by mutated viral T antigens, but the molecular pathogenesis of MCPyV-negative MCC is largely unexplored. Through our MI-ONCOSEQ precision oncology study, we performed...
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