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Article

Merkel cell polyomavirus infection, large T antigen, retinoblastoma protein and outcome in Merkel cell carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jul 2011

Sihto Harri, Kukko Heli, Koljonen Virve, Sankila Risto, Böhling Tom, Joensuu Heikki

Abstract excerpt

PURPOSE: Merkel cell carcinoma (MCC) is rare skin cancer that is often associated with Merkel cell polyomavirus (MCPyV) infection. Polyomaviruses repress tumor suppressor proteins, thus influencing cell-cycle progression, but the effect of MCPyV on the key cell-cycle regulating proteins is poorly understood. EXPERIMENTAL DESIGN: We evaluated expression of the MCPyV large T-antigen (LTA), Ki-67, and the key...

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Share to Antigens, Polyomavirus Transforming
Share to Carcinoma, Merkel Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Viral

Share to Polyomavirus Infections

Share to Retinoblastoma Protein

Share to Skin Neoplasms

Share to Survival Analysis

Share to Tumor Virus Infections

Source

Identifiers

PMID: 21642382
DOI: 10.1158/1078-0432.CCR-10-3363

Genes

MCC
LTA
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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