Article
Genetic variation in IGF-1 and breast cancer risk in Ashkenazi carriers and noncarriers of BRCA1/2 mutations.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) - 1 Sept 2009
Khoury-Shakour Sana, Lejbkowicz Flavio, Barnett-Griness Ofra, Tamir Ada, Pinchev Mila, Rennert Gad
Abstract excerpt
Earlier studies indicate that high circulating levels of insulin-like growth factor-1 (IGF-1) may be associated with premenopausal breast cancer. We studied variations in the IGF-1 gene and the growth hormone (GH1) gene in relation to risk of breast cancer in 667 Ashkenazi Jewish women (321 cases, 346 controls) from a population-based case-control study in Northern Israel, and a clinical series of 331 founder...
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