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Article

Frequency and carrier risk associated with common BRCA1 and BRCA2 mutations in Ashkenazi Jewish breast cancer patients.

American journal of human genetics - 1 Jul 1998

Fodor F H, Weston A, Bleiweiss I J, McCurdy L D, Walsh M M, Tartter P I, Brower S T, Eng C M

Abstract excerpt

Based on breast cancer families with multiple and/or early-onset cases, estimates of the lifetime risk of breast cancer in carriers of BRCA1 or BRCA2 mutations may be as high as 85%. The risk for individuals not selected for family history or other risk factors is uncertain. We determined the frequency of the common BRCA1 (185delAG and 5382insC) and BRCA2 (6174delT) mutations in a series of 268 anonymous...

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Source

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Identifiers

PMID: 9634504
DOI: 10.1086/301903
PMCID: PMC1377227

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Frequency and carrier risk associated with common BRCA1 and BRCA2 mutations in Ashkenazi Jewish breast cancer patients.PMID 9634504Read ↗

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An unaffected individual from a breast/ovarian cancer family with germline mutations in both BRCA1 and BRCA2.Semantic proximity Read ↗

Prevalence and penetrance of BRCA1 and BRCA2 gene mutations in unselected Ashkenazi Jewish women with breast cancer.Semantic proximity Read ↗

A low frequency of non-founder BRCA1 mutations in Ashkenazi Jewish breast-ovarian cancer families.Semantic proximity Read ↗

Analysis of BRCA1/BRCA2 genes' contribution to breast cancer susceptibility in high risk Jewish Ashkenazi women.Semantic proximity Read ↗

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The founder mutations 185delAG and 5382insC in BRCA1 and 6174delT in BRCA2 appear in 60% of ovarian cancer and 30% of early-onset breast cancer patients among Ashkenazi women.Semantic proximity Read ↗

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