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Article

Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2.

Science (New York, N.Y.) - 24 Oct 2003

King Mary-Claire, Marks Joan H, Mandell Jessica B

Abstract excerpt

Risks of breast and ovarian cancer were determined for Ashkenazi Jewish women with inherited mutations in the tumor suppressor genes BRCA1 and BRCA2. We selected 1008 index cases, regardless of family history of cancer, and carried out molecular analysis across entire families. The lifetime risk of breast cancer among female mutation carriers was 82%, similar to risks in families with many cases. Risks appear to...

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Identifiers

PMID: 14576434
DOI: 10.1126/science.1088759

Genes

BRCA1
BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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