Article
Insulin-like growth factor I polymorphism and breast cancer risk in Jewish women.
The Israel Medical Association journal : IMAJ - 1 Oct 2002
Figer Arie, Karasik Yael Patael, Baruch Ruth Gershoni, Chetrit Angela, Papa Moshe Z, Sade Revital Bruchim Bar, Rizel Shulamith, Friedman Eitan, Riezel Shulamith
Abstract excerpt
BACKGROUND: Genes that confer mild or moderate susceptibility to breast cancer may be involved in the pathogenesis of sporadic breast cancer, modifying the phenotypic expression of mutant BRCA1/BRCA2 alleles. An attractive candidate is the insulin-like growth factor I, a known mitogen to mammary ductal cells in vivo and in vitro, whose serum levels were reportedly elevated in breast cancer patients. OBJECTIVE: To...
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