Ashkenazi Jewish population frequencies for common mutations in BRCA1 and BRCA2.

doi:10.1038/ng1096-185

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Article

Ashkenazi Jewish population frequencies for common mutations in BRCA1 and BRCA2.

Nature genetics - 1 Oct 1996

Roa B B, Boyd A A, Volcik K, Richards C S

Abstract excerpt

BRCA1 and BRCA2 are the two major identified causes of inherited breast cancer, with mutations in either gene conferring up to 80-90% lifetime risk of breast cancer in carrier females. Mutations in BRCA1 account for approximately 45% of familial breast cancer and 90% of inherited breast/ovarian c...

Topics

Alleles
BRCA2 Protein
DNA Mutational Analysis
Female
Gene Frequency
Genes, BRCA1
Genetic Carrier Screening
Genetic Testing
Humans
Israel
Jews
Neoplasm Proteins
Risk Factors
Sequence Deletion
Transcription Factors
United States

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