Article
The coding ECP 434(G>C) gene polymorphism determines the cytotoxicity of ECP but has minor effects on fibroblast-mediated gel contraction and no effect on RNase activity.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2009
Rubin Jenny, Zagai Ulrika, Blom Kristin, Trulson Agneta, Engström Ake, Venge Per
Abstract excerpt
Eosinophil cationic protein (ECP) is a secretory protein of the eosinophil granulocyte, a cell involved in innate immunity. Functional studies have implicated ECP in numerous processes, such as tissue remodeling in allergic inflammation and cytotoxicity toward a variety of pathogens. Recent genetic studies have suggested that the ECP 434(G>C) polymorphism resulting in an arg97thr substitution would alter the...
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