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Article

Deletion of the late cornified envelope genes LCE3B and LCE3C may promote chronic hand eczema with allergic contact dermatitis.

Journal of investigational allergology & clinical immunology - 1 Jan 2011

Molin S, Vollmer S, Weiss E H, Weisenseel P, Ruzicka T, Prinz J C

Abstract excerpt

BACKGROUND: Genetically determined defects in epidermal skin barrier function may contribute to the development of irritant and/or allergic contact dermatitis in chronic hand eczema (CHE). OBJECTIVES: To assess whether a deletion in the late cornified envelope genes LCE3B and LCE3C may constitute a genetic predisposition for the development of CHE or any of its subtypes. PATIENTS AND METHODS: A total of 153...

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PMID: 21995181

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