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Article

Immunodeficiency and immune dysregulation associated with proximal defects of T cell receptor signaling.

Current opinion in immunology - 1 Dec 2014

Notarangelo Luigi D

Abstract excerpt

Engagement of the TCR/CD3 complex triggers a cascade of events that result in T lymphocyte activation and promote positive and negative selection of thymocytes, T lymphocyte migration and effector functions, development and activation of regulatory T cells. Gene mutations that abrogate early TCR signaling are associated with profound abnormalities of T lymphocyte development and function both in humans and in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Antigen, T-Cell

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Source

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Identifiers

PMID: 25459000
DOI: 10.1016/j.coi.2014.10.003
PMCID: PMC4254644

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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