Addition of pathology and biomarker information significantly improves the performance of the Manchester scoring system for <i>BRCA1</i> and <i>BRCA2</i> testing

Abstract excerpt

BACKGROUND: Selection for genetic testing of BRCA1/BRCA2 is an important area of healthcare. Although testing costs for mutational analysis are falling, costs in North America remain in excess of US$3000 (UK price can be 690 pounds). Guidelines in most countries use a 10-20% threshold of detecting a mutation in BRCA1/2 combined within a family before mutational analysis is considered. A number of computer-based...

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