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Article

Estimating risk of breast cancer in carriers of BRCA1 and BRCA2 mutations: a meta-analytic approach.

Statistics in medicine - 15 Apr 2007

Fu Rongwei, Harris Emily L, Helfand Mark, Nelson Heidi D

Abstract excerpt

Estimates of penetrance (or risk) of breast cancer among BRCA mutation carriers in published studies are heterogeneous, prohibiting direct combined estimates. Estimates of prevalence of BRCA mutations are more homogeneous and could allow combined estimates of prevalence. We propose a combined estimator of penetrance from combined estimates of the prevalence of BRCA mutations in women with and without breast...

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Source

Identifiers

PMID: 17243094
DOI: 10.1002/sim.2811

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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