Article
Validation of the Manchester scoring system for predicting BRCA1/2 mutations in 9,390 families suspected of having hereditary breast and ovarian cancer.
International journal of cancer - 15 Nov 2014
Kast Karin, Schmutzler Rita K, Rhiem Kerstin, Kiechle Marion, Fischer Christine, Niederacher Dieter, Arnold Norbert, Grimm Tiemo, Speiser Dorothee, Schlegelberger Brigitte, Varga Dominic, Horvath Judit, Beer Marit, Briest Susanne, Meindl Alfons, Engel Christoph
Abstract excerpt
The Manchester scoring system (MSS) allows the calculation of the probability for the presence of mutations in BRCA1 or BRCA2 genes in families suspected of having hereditary breast and ovarian cancer. In 9,390 families, we determined the predictive performance of the MSS without (MSS-2004) and w...
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