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The Manchester Scoring System for predicting BRCA1/2 mutations underperforms in Arabic Omani breast cancer patients.

Journal of genetic counseling - 1 Apr 2025

van Wyk Chantel, Al-Sayegh Hasan, Al-Kiyumi Sara I, Al-Mamari Ghaida S, Al Saegh Abeer A

Abstract excerpt

Risk assessment models that are applied to assess the lifetime risk of cancer and pathogenic variant risk are more commonly used in Western populations. Using these models, without validation, for non-Western populations has been questioned. This study aimed to evaluate the use and consistency of the Manchester Scoring System as a risk assessment model for the Omani population. A retrospective, file-based...

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Source

Identifiers

PMID: 38888083
DOI: 10.1002/jgc4.1939

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Manchester Scoring System for predicting BRCA1/2 mutations underperforms in Arabic Omani breast cancer patients.PMID 38888083Read ↗

Development of a scoring system to screen for BRCA1/2 mutations.Semantic proximity Read ↗

Validation of the Manchester scoring system for predicting BRCA1/2 mutations in 9,390 families suspected of having hereditary breast and ovarian cancer.Semantic proximity Read ↗

Evaluation of BRCA1 and BRCA2 mutations and risk-prediction models in a typical Asian country (Malaysia) with a relatively low incidence of breast cancer.Semantic proximity Read ↗

Pathology update to the Manchester Scoring System based on testing in over 4000 families.Semantic proximity Read ↗

Establishing a family risk assessment clinic for breast cancer.Semantic proximity Read ↗

Prognosis of probability of BRCA1 and BRCA2 mutations carriage in women with compromised family history of breast and/or ovarian cancer.Semantic proximity Read ↗

Selecting a BRCA risk assessment model for use in a familial cancer clinic.Semantic proximity Read ↗

Evaluating breast cancer risk: available models to assess individual breast cancer risk and probability to be a BRCA mutation carrier.Semantic proximity Read ↗

A pivotal study on patients’ selection for BRCA1 and BRCA2 mutations by different models in Libyan breast cancer womenSemantic proximity Read ↗

BRCA1 and BRCA2 mutations in ethnic Lebanese Arab women with high hereditary risk breast cancer.Semantic proximity Read ↗

Addition of pathology and biomarker information significantly improves the performance of the Manchester scoring system for <i>BRCA1</i> and <i>BRCA2</i> testingSemantic proximity Read ↗

A new scoring system for the chances of identifying a BRCA1/2 mutation outperforms existing models including BRCAPRO.Semantic proximity Read ↗

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