Article

Identifying Ashkenazi Jewish <i>BRCA1/2</i> founder variants in individuals who do not self-report Jewish ancestry

2019-08-09

Abstract excerpt

<h4>ABSTRACT</h4> Current guidelines recommend BRCA1 and BRCA2 genetic testing for individuals with a personal or family history of certain cancers. Three BRCA1/2 founder variants — 185delAG (c.68_69delAG), 5382insC (c.5266dupC), and 6174delT (c.5946delT) — are common in the Ashkenazi Jewish population. We characterized a cohort of more than 2,800 research participants in the 23andMe database who carry one or more...

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Literature Corpus work: 0901b523-dfca-539d-8f92-2e507cd8750e
DOI: 10.1101/19001032

Open publication

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