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Article

Pathology update to the Manchester Scoring System based on testing in over 4000 families.

Journal of medical genetics - 1 Oct 2017

Evans D Gareth, Harkness Elaine F, Plaskocinska Inga, Wallace Andrew J, Clancy Tara, Woodward Emma R, Howell Tony A, Tischkowitz Marc, Lalloo Fiona

Abstract excerpt

BACKGROUND: While the requirement for thresholds for testing for mutations in BRCA1/2 is being questioned, they are likely to remain for individuals unaffected by a relevant cancer. It is still useful to provide pretesting likelihoods, but models need to take into account tumour pathology. METHODS: The Manchester Scoring System (MSS) is a well-used, simple, paper-based model for assessing carrier probability that...

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Source

Identifiers

PMID: 28490612
DOI: 10.1136/jmedgenet-2017-104584

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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