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Article

APE1/Ref-1 enhances DNA binding activity of mutant p53 in a redox-dependent manner.

Oncology reports - 1 Feb 2014

Cun Yanping, Dai Nan, Li Mengxia, Xiong Chengjie, Zhang Qinhong, Sui Jiangdong, Qian Chengyuan, Wang Dong

Abstract excerpt

Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a dual function protein; in addition to its DNA repair activity, it can stimulate DNA binding activity of numerous transcription factors as a reduction-oxidation (redox) factor. APE1/Ref-1 has been found to be a potent activator of wild-type p53 (wtp53) DNA binding in vitro and in vivo. Although p53 is mutated in most types of human cancer...

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Identifiers

PMID: 24297337
DOI: 10.3892/or.2013.2892

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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APE1/Ref-1 enhances DNA binding activity of mutant p53 in a redox-dependent manner.PMID 24297337Read ↗

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