A genetic variant in the APE1/Ref-1 gene promoter -141T/G may modulate risk of glioblastoma in a Chinese Han population.

doi:10.1186/1471-2407-11-104

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Article

A genetic variant in the APE1/Ref-1 gene promoter -141T/G may modulate risk of glioblastoma in a Chinese Han population.

BMC cancer - 23 Mar 2011

Zhou Keke, Hu Dezhi, Lu Juan, Fan Weiwei, Liu Hongliang, Chen Hongyan, Chen Gong, Wei Qingyi, Du Guhong, Mao Ying, Lu Daru, Zhou Liangfu

Abstract excerpt

BACKGROUND: The human apurinic/apyrimidinic endonuclease 1/Redox effector factor-1 (APE1/Ref-1) is implicated in tumor development and progression. Recently, the APE1/Ref-1 promoter -141T/G variant (rs1760944) has been reported to be associated with lung cancer risk. Given the importance of APE1/Ref-1 in both DNA repair and redox activity, we speculate that the -141T/G polymorphism may confer individual...

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PMID: 21429202
DOI: 10.1186/1471-2407-11-104
PMCID: PMC3072948

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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