Article
Biological consequences of potential repair intermediates of clustered base damage site in Escherichia coli.
Mutation research - 2 Oct 2009
Shikazono Naoya, O'Neill Peter
Abstract excerpt
Clustered DNA damage induced by a single radiation track is a unique feature of ionizing radiation. Using a plasmid-based assay in Escherichia coli, we previously found significantly higher mutation frequencies for bistranded clusters containing 7,8-dihydro-8-oxoguanine (8-oxoG) and 5,6-dihydrothymine (DHT) than for either a single 8-oxoG or a single DHT in wild type and in glycosylase-deficient strains of E....
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