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Article

Biological consequences of potential repair intermediates of clustered base damage site in Escherichia coli.

Mutation research - 2 Oct 2009

Shikazono Naoya, O'Neill Peter

Abstract excerpt

Clustered DNA damage induced by a single radiation track is a unique feature of ionizing radiation. Using a plasmid-based assay in Escherichia coli, we previously found significantly higher mutation frequencies for bistranded clusters containing 7,8-dihydro-8-oxoguanine (8-oxoG) and 5,6-dihydrothymine (DHT) than for either a single 8-oxoG or a single DHT in wild type and in glycosylase-deficient strains of E....

Topics

DNA Damage
DNA Repair
DNA, Bacterial
DNA, Single-Stranded
DNA-Formamidopyrimidine Glycosylase
Escherichia coli
Escherichia coli Proteins
Guanine
Mutation
Thymine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19540248
DOI: 10.1016/j.mrfmmm.2009.06.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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