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Article

Increased mutability and decreased repairability of a three-lesion clustered DNA-damaged site comprised of an AP site and bi-stranded 8-oxoG lesions.

International journal of radiation biology - 1 Jun 2014

Cunniffe Siobhan, Walker Alexandra, Stabler Robert, O'Neill Peter, Lomax Martine E

Abstract excerpt

PURPOSE: Ionizing radiation induces DNA damage, some of which are present in clusters, defined as two or more lesions within one to two helical turns of DNA by passage of a single radiation track. These clusters are thought to contribute to the detrimental effects of radiation, in part due to the compromised repair of clustered DNA damaged sites. MATERIALS AND METHODS: The repair of three-lesion cluster present...

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Identifiers

PMID: 24597750
DOI: 10.3109/09553002.2014.899449
PMCID: PMC4059193

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Source receipt: pubmed, retrieved 7 Sept 2026.

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