Article
The roles of specific glycosylases in determining the mutagenic consequences of clustered DNA base damage.
Nucleic acids research - 1 Jan 2006
Shikazono Naoya, Pearson Colin, O'Neill Peter, Thacker John
Abstract excerpt
The potential for genetic change arising from specific single types of DNA lesion has been thoroughly explored, but much less is known about the mutagenic effects of DNA lesions present in clustered damage sites. Localized clustering of damage is a hallmark of certain DNA-damaging agents, particularly ionizing radiation. We have investigated the potential of a non-mutagenic DNA base lesion, 5,6-dihydrothymine...
Topics
- DNA Damage
- DNA Glycosylases
- DNA-Formamidopyrimidine Glycosylase
- Deoxyribonuclease (Pyrimidine Dimer)
- Escherichia coli
- Escherichia coli Proteins
- Guanine
- Mutagenesis
- Mutation
- Thymine